![]() Laxative: Oral: Solution: 195 to 300 mL given once or in divided doses Dosing: Geriatricīowel preparation before colonoscopy (off-label use): The ASGE does not recommend use in the elderly (ASGE ) however, some experts suggest that older patients without comorbidities and who cannot tolerate a higher volume preparation may receive magnesium citrate (A-Rahim 2018). Six hours prior to the colonoscopy, administer a second 1 to 1.5 bottle dose followed by clear liquids (three 240 mL glasses) over 1 hour (ASGE A-Rahim 2018). Patient should also be given a clear liquid diet the day prior to the procedure. Split-dose (evening before procedure): Oral: 1 to 1.5 bottles (300 to 450 mL or 10 to 15 oz) in the early evening (ie, between 6 and 8 PM) followed by clear liquids (at least three 240 mL glasses) over 2 hours. Four hours prior to the procedure, administer a second 1.5 bottle dose followed by clear liquids (three 240 mL glasses) over 1 hour (A-Rahim 2018). Single-dose, same-day (for afternoon procedures): Oral: 1.5 bottles (450 mL or 15 oz) taken 8 hours prior to procedure, followed by clear liquids (at least three 240 mL glasses) over 2 hours. There is no standard dosing for administration the following recommendations are suggested by some experts. OTC labeling: When used for self-medication, do not use if on low salt diet Dosage and Administration Dosing: Adultīowel preparation before colonoscopy (off-label use): Note: This preparation should be avoided in patients with renal impairment, heart failure, decompensated cirrhosis, or baseline electrolyte abnormalities (A-Rahim 2018). A randomized, prospective 2-part study supports use of magnesium citrate as an effective and well tolerated low-volume colonoscopy preparation Berkelhammer 2002. Occasional constipation: Treatment of occasional constipation Use: Off Labelīased on the the American Society for Gastrointestinal and Endoscopy (ASGE) guideline for bowel preparation before colonoscopy, routine use of magnesium citrate as a stand-alone colonoscopy preparation is not recommended for routine use due to limited efficacy data and potential toxicity. Laxative effect: Oral solution: 0.5 to 6 hours Use: Labeled Indications Urine (IOM 1997) feces (as unabsorbed drug) Onset of Action Promotes bowel evacuation by causing osmotic retention of fluid which distends the colon with increased peristaltic activity Pharmacokinetics/Pharmacodynamics Absorption GoodSense Magnesium Citrate: 1.745 g/30 mL (296 mL) Excipient information presented when available (limited, particularly for generics) consult specific product labeling.Ĭitroma: 1.745 g/30 mL (296 mL)
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